What is Vydura and how is it used ?

Vydura is a treatment used to treat migraine with or without aura. It is also used as a preventive treatment for adults who experience more than 4 migraine attacks in a month.

The migraine treatment is available as a prescription treatment. It comes in the form of frozen water, which you place on or under your tongue for it to dissolve.

If you are taking the treatment for the first time you should take it once a day and once daily as a preventive migraine treatment. 

How does Vydura Work?

Vydura contains an active ingredient known as rimegepant, an oral CGRP antagonist prescribed based on the frequency and severity of your migraines.

Rimegepant works by inhibiting the activity of CGRP (Calcitonin Gene-Related Peptide), a pain-signaling chemical that triggers migraines.

If you experience migraine attacks it means you have increased levels of CGRP. Remegepant blocks the activities of CGRP by attaching to its receptor.

CGRP  performs 2 functions: Activates migraine attacks and increases the number of migraine attacks in a month.

How to Take Vydura

Vydura water should be taken once for 24 hours. If you are using the treatment to treat migraine that occurs often, you should take one oral Lyophilisate daily.

If you are treating a one-time attack of migraine you should only take 75mg of Rimegepant within 24 hours. Remember to take the treatment only when the need arises.

Follow your doctor's instructions before taking the Rimegepant treatment. Prioritize reading the Vydura Patient Information Leaflet (PIL) first before taking your dose.

The treatment can be taken with or without food. If your mouth is too dry you can drink water first before taking oral Lyophilisate.

What benefits of Vydura have been shown in studies?

Vydura works faster than a placebo in relieving headache pain. After 2 hours, 20% of patients who took Vydura migraine treatment recorded no head pain compared to 12% who took Placebo.

Rimegepant treats other migraine symptoms such as nausea, photophobia, and phonophobia a.Another study showed taking Vydura reduced the number of migraine attacks a patient received per month.

What is the difference between Vydura and Triptan?

Triptan and Vydura work differently in treating migraine. Triptaworkses directly reduce inflammation of blood vessels, therefore relieving migraine symptoms. Vydura works by blocking CGRP activities to reduce swelling, and pain and relieve migraine symptoms.

Alternative treatments for migraine

Before using any treatment option you should discuss it with your GP. Below are some of the alternative migraine treatments you can use :

Botox injections, CGRP monoclonal antibody therapies - Erenumab, Fremanezumab, and Galcanezumab, and magnetic and nerve stimulation techniques are some of the new preventive migraine treatments you can use in place of Vydura.

If you are having frequent migraine attacks and your headache treatment is not working, you can use preventive treatments like Topiramate an epilepsy treatment, heart and high blood pressure treatments such as pizotifen amitriptyline,e, and beta-blocker tablets.

You can also use Triptan treatments to treat migraine. Examples of Triptan medicines include;

• Sumatriptan, 
• Rizatriptan
• Imigran Nasal Spray
• Zomig Nasal Spray
• Zolmitriptan,
• Rizatriptan Orodispersible
• Naratriptan

Triptan treatments work by calming down overactive pain nerves. They help in relieving headaches, nausea, and vomiting.

Author

Warnings

Vydura Warnings 

Who Can Take Vydura?

Vydura migraine treatment can be taken by anyone 18 years and above with a history of migraine. You can take the treatment if you have migraine with or without aura. The treatment is also effective as a preventive medicine if you often get migraine.

However, you need to consult a doctor first before taking  Vydura (Rimegepant) if you:

• are pregnant, breastfeeding, or planning to be pregnant
• have liver condition
• have kidney condition 
• are allergic to any ingredients of the treatment
• Taking Vydura with other Medicines

Other medications may either impact the effectiveness of the migraine treatment or Vydura may affect the impact of the medicines. You should inform your doctor if you are taking any other treatment before taking Vydura.

Examples of the medicines include:

• HIV treatments 
• Narcolepsy treatments.Example Modafinil
• St Johns Wort 
• High blood pressure treatments (Ex: Bosentan)
• Tuberculosis treatments (Ex: Rifampicin)
• Epilepsy treatments (Ex: Phenobarbital)
• Fungal and bacterial infection treatments 

Possible side effects of Vydura migraine treatment 

Nausea is the most common side effect of Vydura, it may affect 1 in 10 people. Some uncommon side effects you should watch out for include shortness of breath and severe rash.

You need to stop taking your treatment and seek immediate medical advice if you experience either of the uncommon side effects.

Please note due to high volumes during a busy month, orders may be delayed by 24-48 hours so please order in advance. Thank you for your understanding.

Once your order has been approved by our UK medical team it will be dispatched via Royal mail. All orders are sent using a tracked and signed for service.

Royal Mail 48 (2-5 days) | £3.49

Estimated delivery within 2-3 working days. Excludes bank holidays. Not a guaranteed service.

Free delivery on orders over £50.

Royal Mail 24 (Next working day) | £4.99

Estimated delivery within 1 working day. Excludes bank holidays. Not a guaranteed service.

Royal Mail Special Delivery Guaranteed by 1pm | £9.95

Order by the 2:00 PM weekday cut-off time for guaranteed delivery by 1:00 PM the next business day.

Orders placed after the cut-off on Friday will be delivered on Tuesday.