Ozempic vs. Mounjaro: Massive 20,000 Participant Study Reveals Dramatic Weight Loss Results
Most people are fighting against obesity and weight-related diseases like diabetes, cancers, high cholesterol levels, and certain heart diseases.
However, certain weight management drugs have become a powerful and effective tool, letting people lose weight and improve their lifestyle.
In weight loss management, two medications i.e. Ozempic and Mounjaro have become a center of attention. But which one is the best?
Recently, a landmark study was conducted in which 18 386 participants were involved. They were provided with these two drugs, offering insight into their precautionary measures, effectiveness, and possible side effects.
Let’s explore more and figure out which one is the winner!
How Was This Study Designed?
In this study (PUBLISHED ON JAMA NETWORK), 18 386 participants of different ages, ethnicities, and genders were included from diverse backgrounds.
These people were randomly asked to take Ozempic or mounjaro for weight loss for 52 weeks.
Moreover,
this study was double-blind, meaning neither the researchers nor the participants knew which medicine was being administered.
The participants received injections every week, making the study less biased and the results more authentic.
The progress of each participant was regularly monitored via blood tests, daily check-ups, and other health assessments.
Which one is the winner Ozempic or Mounjaro?
Ozempic Vs Mounjaro Vs Wegovy
Ozempic
Ozempic is used to treat type 2 diabetes. It contains an active ingredient called semaglutide and acts as an agonist to the GLP-1 receptor.
It regulates blood sugar levels, suppresses appetite, and enhances insulin secretion, managing diabetes and reducing weight.
Ozempic mimics the GLP-1 receptor, regulating your food intake and appetite. It slows down your digestion process and offers feelings of fullness for longer, managing your weight effectively.
Moreover, it also enhances insulin secretion once you eat something, regulating your blood sugar level efficiently.
Participants who received the weekly injections of Ozempic medicine experienced significant weight loss. They lost 12-15% of their initial weight along with improvements in insulin sensitivity, lipid profiles, and blood glucose levels.
Mounjaro
Mounjaro and Zepbound are both brand names for the generic drug, tirzepatide, which is used for weight loss in the UK. It is highly effective in long term weight loss management and mimics GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors.
The dual action makes mounjaro kwikpen more effective in improving metabolic health and promoting weight loss.
Mounjaro injection’s dual agonist approach makes it different from other weight loss medications in the market.
It is given at a higher dose and targets GLP-1 and GIP receptors, enhancing insulin secretion in response to meals, suppressing your hunger, and lowering the digestion process.
These actions make it more effective for obese and diabetic patients.
However, participants who took Mounjaro lost 15-20% of their initial body weight and found this drug more efficient than Ozempic.
The dual agonist action of Mounjaro offered many other advantages like reduced visceral fat and waist circumference, making it a potent drug for weight loss.
Moreover, this study did not evaluate whether or not the participants who lost their weight regained any weight.
Wegovy
Wegovy contains an active ingredient called semaglutide but works at a higher dose. Wegovy works similar to Ozempic but is clinically approved for chronic weight loss management.
Wegovy targets the GLP-1 receptor and slows down the stomach emptying process. If taken at a higher dose, it causes more significant weight loss, reducing your appetite and enhancing insulin secretion.
To buy Wegovy in the UK, you'll need a prescription. You can order it online from pharmacies like Ashcroft Pharmacy. They offer competitive prices, but it's best to compare with other online options. Wegovy is not available over the counter.
Study Findings:
Consistency with Previous Research: The study's results align well with earlier randomized controlled trials (RCTs).
Tirzepatide Effectiveness: In trials where tirzepatide was compared to a placebo:
In placebo-controlled trials, tirzepatide at 10 mg per week led to 82% of patients with type 2 diabetes (T2D) and 96% of those without T2D losing 5% or more of their body weight by 72 weeks.
 Show that tirzepatide (Mounjaro).jpg)
In similarly designed trials, semaglutide at 2.4 mg per week resulted in 73% of individuals with T2D and 92% of those without T2D achieving the same weight loss by 68 weeks.
Head-to-head trial data are limited, but one study found that 5% weight loss was achieved by 69% of T2D patients on mounjaro 5 mg per week, compared to 58% on semaglutide (1 mg per week).
A trial comparing tirzepatide to semaglutide in patients with overweight or obesity but without T2D is underway, with results expected in late 2024.
Resources
https://www.nhs.uk/conditions/obesity/
https://www.nhs.uk/conditions/type-2-diabetes/
https://www.mayoclinic.org/drugs-supplements/tirzepatide-subcutaneous-route/description/drg-20534045
Bottom Line: What is Better for Weight Loss: Mounjaro or Ozempic?
This massive study compared Ozempic and Moujaro with almost 20,000 participants, offering valuable insights into the efficiency, side effects, and safety of these two weight loss drugs.
Both medications were effective in weight management; however, Mounjaro proved to be the “King Kong” due to its dual action.
Moreover, the future of obesity treatment depends on combined therapy, personalized approaches, and continuous research, unveiling innovative solutions and making them approachable to many.
Final Thoughts
Ozempic, Wegovy, and Mounjaro are effective weight loss drugs but their selection depends on an individual's age, health profile, other medications, and weight loss goals.
Although Mounjaro shows more effectiveness than Ozempic, Ozempic will remain an efficient drug for those who want weight loss along with diabetes management .
So, consult with your health care professional and figure out the most appropriate treatment to achieve a healthy weight and lifestyle.
Frequently Asked Question
Why Is Mounjaro Better than Ozempic?
Mounjaro is an agonist of GLP-1 and GIP receptors, reducing A1C levels (blood sugar levels) more efficiently and promoting more weight loss than Ozempic.
Moreover, Mounjaro offers tailored dosing options according to individuals' preferences and needs, making it more effective than Ozempic.
What Strength of Ozempic and Mounjaro Is Best for Weight Loss?
For weight loss, the standard dose of Ozempic is 2.4 mg and is given weekly in the form of an injection. On the other hand, Mounjaro comes in various strengths i.e. 5, 10, and 15 mg, all doses are effective in weight reduction. However, the higher the dose is, the greater will be the weight loss.
How to Speed Up Weight Loss on Ozempic And Mounjaro?
To speed up weight loss with Ozempic or Mounjaro, eat healthy food, do regular exercise, stay well hydrated, get proper sleep, and consult your doctor for personalized advice and better results.
How Many Kilos Can I Lose In a Month with Ozempic and Mounjaro?
With Ozempic, patients can lose 5-10% of their body weight (2-3 kg) during the first month of treatment. However, with Mounjaro, people lose 15-20% of their body weight (3-4 kg) within the same period.
The overall effect depends on an individual's dosage, age, health conditions, and other factors.
